International Journal of Collaborative Research on Internal Medicine & Public Health

First Report of a Providencia stuartii Strain Coproducing a Beta-Metalloenzyme NDM-1 Type and an Oxacillinase Type OXA-48

Introduction: The emergence and dissemination of carbapenemase-producers enterobacterias and their worldwide spread represents a major issue for both clinical practice settings and public health strategies. Their current extensive spread worldwide is an important source of concern due to limited therapeutic options and raised risk of mortality.
Materials and methods: Pus samples obtained from burned patients admitted to the plastic surgery department were analyzed. They were seeded on ordinary and enriched culture media. Depending on the the antimicrobial susceptibility testing, research of metallo-ß-lactamase was done on isolates by EDTA synergy testing, Hodg test and multiplex PCR.
Results: The identification objectified the presence of multiresistant P. stuarti. Imipenem CMI was high (CMI>8 mg). The resistance has also interested other antibiotics with the exception of aztrinam, amikacin and ciprofloxacin. The EDTA synergy testing was positive (φ>5 mm). The Hodge test was negative for both strains. The PCR have demonstrated the presence of resistance genes (blaNDM-1, blaOXA-48).
Conclusion: This study demonstrated that multidrug resistant strains are present in our country. Regular monitoring and documentation of carbapenem resistant is crucial in developing strategies to control infection due to these bacteria.

Author(s):

Karima Warda, Loubna Ait Said, Khalid Zerouli, Khalid Katfy, Kawtar Zahlane

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