Migraine is a highly prevalent condition experienced by women throughout their child bearing age, started from menarche to menopause. It is affected by the oestrogen, female hormonal changes especially during menarche, pregnancy and menopause. Women with migraines have an increase risk for stroke during pregnancy as well as other vascular complications. Treatment should be considered based on the severity of the patient's headache and functional disability. It is important to select the safest and appropriate therapy especially during pregnancy. Sometime migraine treatment is essential in view of increase maternal and foetal risks resulting from acute attacks rather than the potential adverse effects of therapy itself. Non-pharmacologic treatments are preferred because only a few drugs are safe to use during pregnancy and lactation.