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Silent ACTHoma: A subclinical presentation of Cushing’s disease in a 79 year old male

Pituitary adenomas are mostly benign tumors which may be clinically functioning or nonfunctioning. ACTH secreting tumors causing Cushing’s disease are detected in 0.7 to 2.4 per million individuals per year. Most of the cases reported on such ACTHomas are microadenomas (<10mm) and very few macroadenomas (>10mm). We report an unusual case of 79 year-old elderly patient presenting with subclinical Cushing’s disease due to pituitary macroadenoma (ACTHoma) found incidentally. It raises many possibilities of biochemical nature of hormone in such patients or early degradation of hormone. It certainly brings to our attention that more clinical research is needed to find causes of subclinical Cushing’s disease.


Meenal Malviya , Navneet Kumar , Naseer Ahmad

Abstract | Full-Text | PDF

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