International Journal of Collaborative Research on Internal Medicine & Public Health

Preeclampsia and Lipid levels – a case control study

Introduction: Pre-eclampsia occurs in 3-5% of pregnancies and is an important cause of fetal and maternal morbidity and mortality worldwide. The most important feature in preeclampsia is hypertension which is due to vasospastic phenomenon in kidney, uterus, placenta and brain. Objective: The objective of this study was to compare the mean lipid levels in preeclamptic and normal pregnancy.

Methods: This was a case control study and participants were selected on the basis of nonprobability convenient sampling. Patients had singleton pregnancies, diagnosed as having preeclampsia according to the guidelines of Royal College of Obstetricians and Gynecologists. Pregnancy with preexisting hypertension, renal disease and gestational diabetes were excluded. Normotensive women with singleton pregnancies without any medical complication were taken as controls. Lipid profile was determined by enzymatic colorimetric method. Independent Sample t-test was used to compare BP and lipid levels between preeclamptic and control group, p value <0.05 was considered statistically significant. The study protocol was approved by ethical review committee.

Results: Mean triglycerides levels were (254 mg/dl ± 0.45 versus 116.59 ± 4.9) statistically significantly higher in preeclamptic as compared to normal controls (p<0.05). Mean HDL-C levels were (36.92 mg/dl ± 7.70 versus 51 ± 5.46) statistically significantly higher in preeclamptic as compared to normal controls (p<0.05). Mean LDL-C levels were (132.95 mg/dl± 32.26 versus 99.36 ± 17.75) statistically significantly higher in preeclamptic as compared to normal controls (p<0.05).

Conclusion: Preeclamptic women had deranged lipid profile as compared to normal pregnant women.

Author(s):

Musleh Uddin Kalar , Nabila Kalar, Farah Mansoor , Abdul Rehman Malik , Todd Lessley , Susanne Kreimer , Ayesha Abbasi , Muhammad Bilal

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