Estrogen and Progesterone receptor expression in vulvar Condyloma acuminata

Background & objectives: Human papilloma virus is one of the most common sexually transmitted diseases which have different clinical appearances such as Condyloma acuminate (CA) .Its prevalence is more common in women with preponderance in pregnancy which can be attributed to especial hormones such as estrogen and progesterone. The aim of this study was to evaluate the estrogen and progesterone receptor expression in CA lesions of vulva.

Material and Methods: Patients referred to outpatient clinic of Emam Reza hospital suspected of having CA lesions from September 2009- March 2011 were evaluated. Biopsy specimens from CA lesions were taken from 39 patient. Tissue samples was collected and after pathologist confirmation, immunostaining was done on cryostat sections by the peroxidase –antiperoxidase method to measure progesterone and estrogen receptors.

Results: From 37 suspected specimens 25 samples which were confirmed by pathologist To be condyloma acuminata evaluated by IHC;PR was positive in 77,8% of all contaminated samples and 15.4% in normal tissue (p=.000).ER was positive in 33.3% and 25% in contaminated and normal samples respectively.

Conclusion: According to the results of this study there is a significant difference in PR receptor expression in CA of vulva

Author(s): Taravat Fakheri, Mandana Afsharian , Ehsan Malekianzadeh, Sedigheh Khazaei, Babak Izadi, Malek Kanani

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