Drugs have been created for the benefits of humans but unfortunately misused throughout its existence. In order to eliminate or at least to decrease its abuse, it is important to examine the contributory factors of drug abuse and the accessibility of drugs. For examples, learn how humans come in contact with drugs, the mentality behind drugs taking, populations vulnerable to abuse, and the ways of distributing and obtaining illicit drugs without getting caught for the past many years. In sum, this review attempts to discuss the contributory factors of drug abuse and how if any, advanced technology has impacted on substance use; specifically, the genetic influence on substance abuse and the availability of drugs as a result of advanced technology. This would help the government and NGO to generate the effective precautions and interventions.