Objective: Blood pressure effect of excessive salt intake was analyzed in relation to angiotensin I-converting enzyme (ACE) polymorphisms in young male normotensive African Tanzanians. Design and Methods: We grouped 33 young male normotensive African Tanzanians. Their blood pressure were as follows, systolic blood pressure (SBP) <120mmHg and diastolic blood pressure (DBP) <80 mmHg. Healthy male subjects participated in a 2-week intervention consisting of seven days of salt loading (140 mEq of NaCl) followed by diuretic treatment for a period of one week. Results: In 33 subjects, ACE genotyped DD, DI and II polymorphisms was 6, 17, 10, respectively. In the base line, there was no significant difference in SBP among the DD, DI and II genotypes. However, SBP among the DD, DI and II genotypes was significantly different after salt loading for 4 and 7days. This tendency was also observed in the diuretic phase. There was no significant difference in DBP and HR among ACE polymorphism genotypes during the experimental period. Conclusion: We observed an interaction between SBP after salt ingestion and ACE insertion/deletion (I/D) polymorphisms in young male normotensive Tanzanians.
Negishi H, Yasui N, Njelekela M, Juman S, Miki T, Mtabaji J, Yamori Y, Ikeda K