Adult onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology that can raise serious positive and differential diagnosis problems due to the particular complexity of clinical and biological data. One of the most common presentations of the disease is fever of unknown origin. In Romania is also very rare, therefore we present a case report of AOSD who became the first case to be notified in our hospital until now. A 24-year-old woman with persistent fever of unknown etiology, rash, arthralgia and myalgia of three weeks duration presented to our hospital. The purpose of this presentation is to describe a case which put uncertainty on differential diagnosis and to review the literature about AOSD from a primary care perspective.