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Abstract

Comparative analysis of serum protein electrophoresis’ profiles of people infected with HIV and those not infected with HIV in Kinshasa

Introduction: It is necessary to consider the analysis of electrophoresis’ profiles of serum proteins as an alternative and less expensive for the biological monitoring of patients infected by HIV in countries with limited resources.

Objective: The aim of the study was to establish a comparison between the electrophoresis’ profile of sera proteins of people infected by HIV naïve of treatment and people not infected by HIV.

Method: A transversal study was conducted at AMO-CONGO Kasa-Vubu in Kinshasa with people who came for a voluntary HIV screening test. Eighty one people, naïve of HAART, participated voluntarily in the study. HIV screening was systematically done according to WHO recommendations. Blood sample was obtained in a dry tube for the electrophoresis’ profile of sera proteins, and in a tube with EDTA for numeration of CD4 for HIV positive patients. The statistical test of Chi-squared was used for qualitative data, and the test of Student for quantitative data.

Result: Out of 81 volunteers, 30 were confirmed HIV positive and 51 negative. The results obtained demonstrate that HIV infection is associated with a hyperprotidémie (60%), a hypoalbuminémie (100%) also a hypergammaglobulinemia (100%) according to CD4 level. No significant modification was observed for the alpha and beta-globulins.

Conclusion: The HIV infection induces some significant modifications of different fractions of sera proteins according to immune status.


Author(s):

KAMANGU NTAMBWE ERICK, KALALA LUNGANZA RICHARD, MVUMBI LELO GEORGES, MESIA KAHUNU GAUTHIER



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