Background: The relationship between shift work and cardiovascular disease is controversial.
Objectives: The present study aimed to assess the relationship between shift work and arterial age and to identify predictors of early arterial aging.
Methods/Study Design: A total of 61 workers, 77% working in 2 or more shifts, underwent arteriography. Arterial age (AA), brachial and aortic augmentation index (Aix Brach and Aix Ao) and pulse wave velocity (PWV) were assessed. The participants were questioned about smoking habits, cardiovascular family and personal history, physical work and number of shifts.
Results/Findings: Aix Brach was: -40±29 %, AixAo: 16±1.71%, PWV: 8.06±1.44 m/s, AA: 41±15 years. The number of shifts was significantly associated with Aix Brach (p<0.01) and Aix Ao (p<0.01) (Multiple R=0.875, F<0.01); PWV (p<0.01) and AA (p=0.0001) (Multiple R=0.922, F<0.01). Multiple regression analysis revealed significant associations between arterial age and smoking (p=0.0008), positive cardiovascular family history (p=0.023) and physical work (p=0.0029) (Multiple R=0.758, F<0.01). Early arterial aging was more likely in shift workers compared to the other participants (OR=1.189, 95%CI=0.346-4.089).
Conclusion: Shift work, smoking, positive cardiovascular family history and physical work predict early arterial aging.
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