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Abstract

An estimation of the efficiency of thrombolytic therapy in patients with myocardial infarction

Introduction: Myocardial infarction (MI) is the most prognostic terrible disease. It is caused by the blockage of a coronary artery by a thrombus or clot. This is usually the result of a rupture of an atherosclerotic plaque within the artery. The heart muscle supplied by that artery is damaged due to the lack of oxygen (ischaemia). Objective: To study the efficiency of Thrombolytic therapy (TLT) in the emergency department of the 4th City Clinic Hospital of Minsk an estimation was made of the efficiency of TLT for two thrombolytic medications: exogene tissue activator plasminogene alteplasa (Actelyse) and Streptokinase.

Method: A total of 23 adult were divided into two groups: Alteplasa group and Streptokinase group. The effectiveness was observed after thrombolytic therapy.

Result: The diagnosis of AMI was based on WHO criteria, which included clinical symptoms (typically but not exclusively chest pain), typical changes in the 12-lead electrocardiogram (ST segment elevation, which provides the most immediate indication of the diagnosis of AMI for patients requiring thrombolytic therapy for AMI) and myocardial enzyme elevation (Creatine Kinase(CC-MB), Troponin). Male and female correlation was 14:8. An average was 64 years. 16 patients (70%) experienced arterial hypertension, 3 patients (13%) - diabetes. One patient had died.

Conclusion: The most important factor determining the choice of treatment tactics and effectiveness of TLT is the time interval from the beginning of anginal attack prior to treatment. The sooner started TLT, the higher the efficiency is.


Author(s): Margarita Strelcenia , Gubkin S.V.

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